Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles

• DOI: 10.1039/b905068j
• Publication Date: 2009-05-28T08:30:31Z
• Authors: César Sánchez; Aaroa P. Salas; Alfredo F. Braña; Martina Palomino; Antonio Pineda-Lu...; Rodrigo J. Carbajo; Carmen Méndez; Francisco Moris; José A. Salas
• Keywords: 0303 health sciences; Molecular Structure; Carbazoles; Antineoplastic Agents; Staurosporine; Streptomyces; Indole Alkaloids; 3. Good health; 03 medical and health sciences; Cell Line, Tumor; Multigene Family; Combinatorial Chemistry Techniques; Humans; Protein Kinase Inhibitors; Cell Proliferation; Plasmids

We report the generation of novel glycosylated indolocarbazoles by combinatorial biosynthesis, and the identification of two novel potent and selective compounds inhibitors of JAK2 and Ikkb kinases.