A robust, sensitive, and versatile HMBC experiment for rapid structure elucidation by NMR: IMPACT-HMBC

• DOI: 10.1039/c000964d
• Publication Date: 2010-04-01T12:00:12Z
• Authors: Julien Furrer
• Keywords: 01 natural sciences; 0104 chemical sciences

A robust, versatile and easy to optimize HMBC experiment for complex organic structure elucidation which has been experimentally tested on cholesteryl acetate, cyclosporine and isopropylidene glycerol is described. The proposed experiment, IMPACT-HMBC (improved and accelerated constant-time heteronuclear multiple-bond correlation), combines sensitivity, easy experimental setup and can be recorded with short recovery times.