Glucosamine hydrochloride functionalized tetraphenylethylene: A novel fluorescent probe for alkaline phosphatase based on the aggregation-induced emission

• DOI: 10.1039/c002894k
• Publication Date: 2010-05-10T11:30:11Z
• Authors: Qi Chen; Ning Bian; Chun Cao; Xi-Long Qiu; Ai-Di Qi; Bao-Hang Han
• Keywords: Glucosamine; Stilbenes; Fluorometry; Triazoles; Alkaline Phosphatase; 01 natural sciences; Fluorescent Dyes; 0104 chemical sciences

Grafting of glucosamine hydrochloride moieties to tetraphenylethylene (TPE) motif furnished a novel cationic water-soluble tetraphenylethylene derivative (GH-TPE). With aggregation-induced emission properties, GH-TPE was used for fluorometric detection to alkaline phosphatase through enzyme-triggered de-aggregation of the ensemble of GH-TPE and substrate.