In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

• DOI: 10.1039/c0cc05077f
• Publication Date: 2011-02-08T12:30:27Z
• Authors: Manuela Tosin; Yuliya Demydchuk; James S. Parascan...; Covadonga Blasco Per; Finian J. Leeper; Peter F. Leadlay
• Keywords: Polyketide synthase; Malonyl-CoA

Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted malonyl carba(dethia)-N-acetyl cysteamines, generated vivo from hydrolysis corresponding methyl esters.