Function of Plectranthus barbatus herbal tea as neuronal acetylcholinesterase inhibitor

• DOI: 10.1039/c0fo00070a
• Publication Date: 2010-12-13T09:30:22Z
• Authors: Pedro L. V. Falé; Paulo J. Amorim M...; M. Helena Florêncio; Lia Ascensão; Maria Luísa M. Se...
• Keywords: Rosmarinic acid; Plectranthus; Acetylcholinesterase inhibitor

This study aims to determine the function of Plectranthus barbatus (Lamiaceae) herbal tea as inhibitor brain acetylcholinesterase (AChE) activity. To accomplish this objective well its main component, rosmarinic acid were administered laboratory animals (rats) and effect on AChE activity was evaluated. The metabolites in plasma also undertaken. water extract intragastrically intraperitoneally. When plant administered, vestigial amounts from P. compounds present rat plasma, but none found brain, although inhibition detected. However, when intraperitoneally, all brain. highest concentrations compounds/metabolites 30 min after administration. An 29.0 ± 2.3% 24.9 3.7% observed 60 intraperitoneal administration, respectively. These values higher than those expected, taking into account quantity detected which suggests that other active or may be non-detectable amounts. results prove administration aqueous can reach act inhibitor.