Metabolomics study of diabetic retinopathy using gas chromatography–mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine

• DOI: 10.1039/c0mb00341g
• Publication Date: 2011-05-11T10:00:17Z
• Authors: Xiang Li; Xiangxia Luo; Xin Lu; Junguo Duan; Guowang Xu
• Keywords: Western medicine; Metabolic pathway

Diabetic retinopathy (DR) is a serious microvascular syndrome of diabetes, and one the most frequent causes blindness in world. It has three progressive stages with complex metabolic deregulations holistic system Western medicine. Chinese medicine classifies DR into two different types; integrating to treat validated therapeutic approach China. In this research, systemic metabolite change was investigated from viewpoint both medicine, using metabolomics based on gas chromatography–mass spectrometry. The data revealed perspectives can reflect patterns, development differentiation DR, also had good correlation complementarity characterizing process DR. Potential biomarkers indicated alterative modes metabolites pathways disease, e.g. disturbance fatty acids, amino acids glucose, etc. results showed usefulness validity combining study subtypes mechanisms involved.