The traceless Staudinger ligation for indirect18F-radiolabelling

• DOI: 10.1039/c0ob00564a
• Publication Date: 2010-11-22T13:00:14Z
• Authors: Laurence Carroll; Sophie Boldon; Romain Bejot; Jane E. Moore; Jérôme Declerck; Véronique Gouverneur
• Keywords: Staudinger reaction

The Staudinger ligation of phosphine-substituted thioesters with (18)F-fluoroethylazide has been successfully applied to access (18)F-labelled molecules in radiochemical yields superior 95%; the first fluorous variant a radio-ligation validated.