Pd/Cu-catalyzed cascade Sonogashira coupling/cyclization reactions to highly substituted 3-formyl furans
Sonogashira coupling
Coupling reaction
Cascade reaction
DOI:
10.1039/c0ob00985g
Publication Date:
2010-12-20T15:00:42Z
AUTHORS (6)
ABSTRACT
An efficient palladium/copper-catalyzed approach to the synthesis of highly substituted 3-formyl furans from reactions readily available α-bromoenaminones with terminal alkynes has been developed. This methodology was realized by cascade Sonogashira coupling and subsequent intramolecular cyclization.
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