Pd/Cu-catalyzed cascade Sonogashira coupling/cyclization reactions to highly substituted 3-formyl furans

• DOI: 10.1039/c0ob00985g
• Publication Date: 2010-12-20T15:00:42Z
• Authors: Jingyu Yang; Chengyu Wang; Xin Xie; Hongfeng Li; Ende Li; Yanzhong Li
• Keywords: Sonogashira coupling; Coupling reaction; Cascade reaction

An efficient palladium/copper-catalyzed approach to the synthesis of highly substituted 3-formyl furans from reactions readily available α-bromoenaminones with terminal alkynes has been developed. This methodology was realized by cascade Sonogashira coupling and subsequent intramolecular cyclization.