Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging – the next dimension

• DOI: 10.1039/c0sc00570c
• Publication Date: 2011-01-07T15:00:58Z
• Authors: Nicholas Stone; Marleen Kerssens; Gavin Rhys Lloyd; Karen Faulds; Duncan Graham; Pavel Matousek
• Keywords: Surface-Enhanced Raman Spectroscopy; Data cube

SESORS - Surface enhanced spatially offset Raman spectroscopy–imaging is explored for the first time in this study. Multiplexed surface scattering (SERS) signals have been recovered non-invasively from a depth of 20 mm tissues and reconstructed to produce false colour image. Four unique 'flavours' SERS nanoparticles (NPs) were injected into × 50 porcine tissue block at corners 10 square. A transmission data cube was acquired over an 11 pixel grid made up 2 steps. The using peak intensities each nanoparticles. image relative signal levels produced, demonstrating capability multiplexed imaging deep spectroscopy. secondary but no less significant achievement demonstrate that can be samples order 45–50 thick. This step forward ability detect identify vibrational fingerprints within offers opportunity adapt these particles approach clinical setting disease diagnosis.