First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

• DOI: 10.1039/c1cc10787a
• Publication Date: 2011-03-31T09:00:26Z
• Authors: Guillaume Mercey; Tristan Verdelet; Géraldine Saint-A...; Emilie Gillon; Alain Wagner; Rachid Baati; Ludovic Jean; Florian Nachon; Pierre-Yves Renard
• Keywords: 0303 health sciences; Erythrocytes; Obidoxime Chloride; Molecular Structure; [CHIM.ORGA]Chemical Sciences/Organic chemistry; Pyridines; Soman; 610; Pyridinium Compounds; 01 natural sciences; Organophosphates; 0104 chemical sciences; 3. Good health; 03 medical and health sciences; Organophosphorus Compounds; Oximes; Acetylcholinesterase; Humans; Cholinesterase Inhibitors

AbstractThe title compounds (I) are extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as that of HI‐6, obidoxime, TMB‐4 and HL‐7.