The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABACreceptor

• DOI: 10.1039/c1cc15816c
• Publication Date: 2011-12-06T09:38:04Z
• Authors: Izumi Yamamoto; Meredith J. T. Jo...; Navnath Gavande; Munikumar R. Dodd...; Mary Chebib; Luke Hunter
• Keywords: Aminobutyric acid; GABAB receptor

The conformational behaviour and GABA receptor activity of the different stereoisomers 2,3-difluoro-4-aminobutyric acid are described. Two enantiomeric GABAC-active ligands identified, one which is an agonist while other antagonist. results support existing QSAR model bioactive geometry at GABAC.