In vitro synthesis and stabilization of amorphous calcium carbonate (ACC) nanoparticles within liposomes

• DOI: 10.1039/c1ce05153a
• Publication Date: 2011-05-10T13:30:17Z
• Authors: Chantel C. Tester; Ryan E. Brock; Ching-Hsuan Wu; Minna R. Krejci; Steven Weigand; Derk Joester
• Keywords: Amorphous calcium carbonate; Particle (ecology); Amorphous calcium phosphate

We show that amorphous calcium carbonate (ACC) can be synthesized in phospholipid bilayer vesicles (liposomes). Liposome-encapsulated ACC nanoparticles are stable against aggregation, do not crystallize for at least 20 h, and ideally suited to investigate the influence of lipid chemistry, particle size, soluble additives on situ.