Intracellular mapping with SERS-encoded gold nanostars

• DOI: 10.1039/c1ib00029b
• Publication Date: 2011-08-10T06:30:23Z
• Authors: Laura Rodríguez-L...; Zeljka Krpetic; Silvia Barbosa; Ramón A. Alvarez-...; Luis M. Liz-Marzán; Ian A. Prior; Mathias Brust
• Keywords: Optical Phenomena; Biological Transport, Active; Metal Nanoparticles; Surface Plasmon Resonance; Silicon Dioxide; Spectrum Analysis, Raman; 01 natural sciences; High-Throughput Screening Assays; 0104 chemical sciences; Microscopy, Electron, Transmission; Humans; Gold; HeLa Cells

Here we report on the design, synthesis and application of small, highly bright, star-shaped SERS encoded single nanoparticles with ability providing an optical signal upon excitation near infrared light. These particles are colloidally stable, fully biocompatible can be internalized into living cells for intracellular imaging.