Quasi-biomimetic ring contraction promoted by a cysteine-based nucleophile: Total synthesis of Sch-642305, some analogs and their putative anti-HIV activities

• DOI: 10.1039/c1sc00221j
• Publication Date: 2011-06-20T09:00:34Z
• Authors: Alpay Dermenci; Philipp S. Selig; Robert A. Domaoal; Krasimir A. Spasov; Karen S. Anderson; Scott J. Miller
• Keywords: Biomimetic Synthesis; Realm

Cysteine plays a number of important functional and structural roles in nature, often the realm catalysis. Herein, we present an example cysteine-promoted Rauhut-Currier reaction for potentially biomimetic synthesis Sch-642305 related analogs. In this key step discuss interesting new discoveries importance substrate-catalyst recognition, as well cysteine's features. Also, investigate activity four analogs HIV-infected T-cells.