Ruthenium-catalyzed intramolecular carbocyclization of alkynes with an sp3 carbon involving an oxidative deprotonation process

• DOI: 10.1039/c1sc00423a
• Publication Date: 2011-08-05T08:30:50Z
• Authors: Bo-Xiao Tang; Ren-Jie Song; Cui-Yan Wu; Zhi-Qiang Wang; Yu Liu; Xiao-Cheng Huang; Ye-Xiang Xie; Jin-Heng Li
• Keywords: Alkyne; Amide

A novel RuCl3-catalyzed intramolecular oxidative hydration–deprotonation–cyclization method was developed for the synthesis of substituted quinolinones. The serves as first example direct carbocyclization an alkyne with sp3carbon at α-position amide through deprotonation process.