Asymmetric synthesis of α-amino boronate esters via organocatalytic pinacolboryl addition to tosylaldimines

• DOI: 10.1039/c2cc00020b
• Publication Date: 2012-02-17T10:03:09Z
• Authors: Cristina Solé; Henrik Gulyás; Elena Fernández
• Keywords: Nucleophilic Addition

Organocatalytic nucleophilic pinacolboryl addition from in situ generated MeO− → B2pin2 to CN double bond can be performed enantioselectively with the aid of chiral phosphines, which promote enantiofacial differentiation course C–B formation.