Synthesis and evaluation of triazole-linked poly(ε-caprolactone)-graft-poly(2-methyl-2-oxazoline) copolymers as potential drug carriers

• DOI: 10.1039/c2cc30191a
• Publication Date: 2012-01-23T11:37:39Z
• Authors: Brieuc Guillerm; Vincent Darcos; Vincent Lapinte; Sophie Monge; Jean Coudane; Jean-Jacques Robin
• Keywords: Oxazoline; Caprolactone; Triazole; Alkyne

Well-defined graft copolymers were obtained using a copper-catalysed azide–alkyne Huisgen's cycloaddition click reaction from both biocompatible and non-toxic poly(ε-caprolactone) poly(2-methyl-2-oxazoline) homopolymers. Resulting amphiphilic proved to form micelles that could be used as potential drug carriers.