Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo

• DOI: 10.1039/c2cc30265a
• Publication Date: 2012-02-17T09:34:45Z
• Authors: Yi Zhou; Ju-Ying Li; Kai-Hui Chu; Ke Liu; Cheng Yao; Jing-Yun Li
• Keywords: Hypochlorous acid

We report three new water-soluble dihydrofluorescein-ether probes FCN1, FCN2 and FCN3 for the detection of hypochlorous acid (HOCl), which were designed on basis a specific HOCl-promoted oxidation reaction. This work also provided useful method to monitor accumulated HOCl in organelles using zebrafish model.