Solvent dependence of helix stability in aromatic oligoamide foldamers

• DOI: 10.1039/c2cc31533e
• Publication Date: 2012-04-11T12:30:26Z
• Authors: Ting Qi; Victor Maurizot; Hiroki Noguchi; Thiraporn Charoen...; Brice Kauffmann; Makoto Takafuji; Hirotaka Ihara; Ivan Huc
• Keywords: 01 natural sciences; 0104 chemical sciences

A new helical aromatic oligoamide foldamer, bearing triethyleneglycol side chains for solubility in a broad range of media, was prepared. The stability of the helical conformation was assessed in various solvents and shown to vary greatly and unexpectedly. Stability was remarkably enhanced in methanol-water mixtures.