A dramatic concentration effect on the stereoselectivity of N-glycosylation for the synthesis of 2′-deoxy-β-ribonucleosides

• DOI: 10.1039/c2cc33155a
• Publication Date: 2012-05-22T18:21:41Z
• Authors: Fei Yang; Yugen Zhu; Biao Yu
• Keywords: Glycosylation; Molecular Conformation; Stereoisomerism; Purine Nucleosides; 01 natural sciences; 0104 chemical sciences

A dramatic concentration effect on the stereoselectivity of N-glycosylation, which is attributable to a low-concentration-facilitated remote-participation, has been disclosed, leading convenient synthesis 2′-deoxy-β-ribonucleosides biological significance.