Light-triggered reversible assemblies of azobenzene-containing amphiphilic copolymer with β-cyclodextrin-modified hollow mesoporous silica nanoparticles for controlled drug release

• DOI: 10.1039/c2cc33995a
• Publication Date: 2012-08-22T09:02:17Z
• Authors: Xiao Mei; Shun Yang; Dongyun Chen; Najun Li; Hua Li; Qingfeng Xu; Jianfeng Ge; Jianmei Lu
• Keywords: Models, Molecular; Surface-Active Agents; Light; Delayed-Action Preparations; beta-Cyclodextrins; Nanoparticles; 02 engineering and technology; Silicon Dioxide; 0210 nano-technology; Azo Compounds; Porosity

Hollow mesoporous silica nanoparticles (HMSs) were modified by β-cyclodextrin via a "click" reaction, an amphiphilic copolymer with a trans-azobenzene structure was then assembled onto β-cyclodextrin to cover the surface of the HMSs. The prepared nanocomposites can release drugs in a "release-stop-release" manner by converting light irradiation.