nBu4NI-catalyzed direct synthesis of α-ketoamides from aryl methyl ketones with dialkylformamides in water using TBHP as oxidant

• DOI: 10.1039/c2cc35279f
• Publication Date: 2012-08-23T15:03:01Z
• Authors: Wen-Peng Mai; Hui-Hui Wang; Zhi-Cheng Li; Jin-Wei Yuan; Yong-Mei Xiao; Liang-Ru Yang; Pu Mao; Ling-Bo Qu
• Keywords: Formamides; Water; Ketones; Oxidants; Amides; 01 natural sciences; Catalysis; 6. Clean water; 0104 chemical sciences; tert-Butylhydroperoxide

A novel and easy practical direct synthesis of α-ketoamides has been developed without metals in water. This procedure was catalyzed by nBu4NI using TBHP as oxidant from simple substrates, aryl methyl ketones dialkylformamides.