Palladium–copper-cocatalyzed intramolecular oxidative coupling: an efficient and atom-economical strategy for the synthesis of 3-acylindoles

• DOI: 10.1039/c2cc37805a
• Publication Date: 2013-01-03T16:05:13Z
• Authors: Xiao-Feng Xia; Lu-Lu Zhang; Xian-Rong Song; Yan-Ning Niu; Xue-Yuan Liu; Yong-Min Liang
• Keywords: Indoles; Oxidative Coupling; Cyclization; 01 natural sciences; 7. Clean energy; Catalysis; Copper; Palladium; 0104 chemical sciences

A new and efficient catalytic approach to the synthesis of 3-acylindoles under Pd–Cu-cocatalyzed oxidative conditions is demonstrated. tert-Butyl hydroperoxide (TBHP) acts not only as oxidant, but also an oxygen source in approach. The process allows quick atom-economical assembly from readily available starting materials tolerates a broad range functional groups.