Self-assembled metalla-rectangles bearing azodipyridyl ligands: synthesis, characterization and antitumor activity

• DOI: 10.1039/c2dt31014g
• Publication Date: 2012-10-16T14:00:20Z
• Authors: Vaishali Vajpayee; Sunmi Lee; Seol-Hee Kim; Se Chan Kang; Timothy R. Cook; Hyunuk Kim; Dong Wook Kim; Shashi Verma; Myoung Soo Lah; In Su Kim; Ming Wang; Peter J. Stang; Ki-Whan Chi
• Keywords: Hydrazine (antidepressant)

Sixteen arene–Ru based molecular-rectangles were self-assembled in high yields by the equimolar mixing of acceptors (Aa–Ad) with various azopyridyl ligands (1,2-di(pyridyl-4yl)diazene (L1), 1,2-bis(pyridin-4-ylmethylene)hydrazine (L2), 1,2-bis(1-(pyridin-4-yl)ethylidene)hydrazine (L3), (L4)) nitromethane–methanol solutions. These new fully characterized a host analytical techniques including elemental analysis, 1H and 13C NMR HR-ESI-MS. The solid-state structures two (1b 4d) determined single crystal X-ray diffraction data. UV-visible fluorescence studies also carried out for entire suite rectangles. As recent similar complexes, anti-proliferative activities these complexes evaluated against SK-hep-1 (liver cancer) A-549 (lung human cancer lines. Additionally, cellular pharmacology intracellular localizations AGS (gastric cells selected (1c, 1d 4c) apoptosis microscopy studies. confirm that inhibit cell cycle progression to G0 phase, contrast cisplatin which arrests growth G2 phase.