Chitosan-based synthesis of magnetically-driven nanocomposites with biogenic magnetite core, controlled silver size, and high antimicrobial activity

• DOI: 10.1039/c2gc35545k
• Publication Date: 2012-06-29T08:32:18Z
• Authors: Zdenka Marková; Karolína Šišková; Jan Filip; Klára Šafářová; Robert Prucek; Aleš Panáček; Milan Kolář; Radek Zbořil
• Keywords: Silver nanoparticle

We report a new procedure, exploiting "green" chemistry, resulting in biocompatible magnetically-driven nanocomposites with high antibacterial and antifungal activities against ten tested bacterial strains four Candida species. The consist of silver nanoparticles (NPs), biogenic magnetite NPs isolated from magnetotactic bacteria, an environmentally friendly polymer – chitosan. These hybrids were prepared using acidified chitosan suspension to cover by cross-linking method, followed employing the NH2 groups for reduction salt alkaline medium. Thus, acts as (i) matrix surrounding NPs, (ii) reducing agent ions, (iii) linker between magnetic NPs. size total amount involved can be simply controlled initial concentration used reaction mixture. as-prepared reveal increased bactericidal activity when compared previously reported systems which not green synthetic routes. use uniform shape size, absence any other during synthesis, simple control loading, character matrix, antimicrobial effect predetermine developed targeted applications biomedicine.