Proteomic identification of plasma biomarkers in uterine leiomyoma

• DOI: 10.1039/c2mb05453a
• Publication Date: 2011-12-23T12:09:23Z
• Authors: Chao-Po Lin; Yi-Wen Chen; Wen-Hsin Liu; Hsiu-Chuan Chou; Yi-Ping Chang; Szu-Ting Lin; Ji-Min Li; Shiou-Fen Jian; Ying-Ray Lee; Hong-Lin Chan
• Keywords: Identification; Uterine Leiomyoma

Recent progresses in quantitative proteomics have offered opportunities to discover plasma proteins as biomarkers for tracking the progression and understanding molecular mechanisms of uterine leiomyomas. In present study, samples were analyzed by fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) differentially expressed identified matrix assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF MS). total, 20 been firmly representing 13 unique gene products. These mainly functioned transportation (such apolipoprotein A-I) coagulation fibrinogen gamma chain). Additionally, our proteomic approach has numerous previous reported markers leiomyomas such alpha-1-antitrypsin. On contrary, we presented several putative including afamin, A-I, carbonic anhydrase 1, beta chain, gelsolin, hemopexin, leucine-rich alpha-2-glycoprotein, serotransferrin vitamin D-binding protein which not may be associated with development disease. summary, report a comprehensive patient-based identification potential The utilizing these screening treating warrants further investigations.