The first ratiometric fluorescent probes for aminopeptidase N cell imaging

• DOI: 10.1039/c2ob26564h
• Publication Date: 2012-11-06T09:34:11Z
• Authors: Laizhong Chen; Wei Sun; Jing Li; Zhenzhen Liu; Zhao Ma; Wei Zhang; Lupei Du; Wenfang Xu; Hao Fang; Minyong Li
• Keywords: Live cell imaging

In the current paper, three activity-based colorimetric and ratiometric fluorescent probes based on a naphthalimide fluorophore were well designed synthesized, which can be recognized hydrolyzed by aminopeptidase N (APN) at both enzymatic cellular level following emission wavelength change from blue to green light. As result, these molecules successfully identified as first for APN cell imaging.