A new approach for modular polymer–polymer conjugations via Heck coupling

• DOI: 10.1039/c2sc20402a
• Publication Date: 2012-05-16T10:03:31Z
• Authors: Matthias Winkler; Lucas Montero de ...; Christopher Barne...; Michael A. R. Meier
• Keywords: Moiety; Heck Reaction; Coupling reaction; Methyl acrylate

Heck coupling reactions are introduced as a modular, very efficient and highly orthogonal method for polymer–polymer conjugation. Several diblock triblock copolymers (5200 Da ≤ Mn 17300 Da, 1.08 PDI 1.33) were prepared via of acrylate-terminated aryliodide-terminated polymers. The performed using the so-called Jeffery's conditions, which allowed use equimolar amounts reacting polymers low reaction temperatures. Acrylated poly(ethylene glycol) monomethyl ether (PEG), poly(ε-caprolactone) (PCL) synthesized head-to-tail selective acyclic diene metathesis (ADMET) polymerisation have been successfully conjugated with both PEG PCL containing an aryliodide moiety.