Translocation of polyarginines and conjugated nanoparticles across asymmetric membranes

• DOI: 10.1039/c2sm26519b
• Publication Date: 2012-10-30T13:30:18Z
• Authors: Zhen-lu Li; Hong-ming Ding; Yu-qiang Ma
• Keywords: Dissipative particle dynamics; Cell membrane; Nanomaterials

Understanding how cell-penetrating peptides translocate across cell membranes is of great importance in biomedicine. In this paper, we study the interactions between polyarginines and asymmetric by using coarse-grained molecular dynamics simulations. It found that a peptide has probability to penetrate through membrane because transmembrane potential difference; however, it difficult for single spontaneously while multiple can pore-mediated processes. Further, also provide insights into transporting ability polyarginines, find transport hydrophobic as well hydrophilic particles membranes, where translocation particle easier than one. The present help better understand with may give some new suggestions on design future nanomaterials drug delivery.