A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells

• DOI: 10.1039/c3cc38471c
• Publication Date: 2013-01-18T10:30:18Z
• Authors: Ting Guo; Lei Cui; Jiaoning Shen; Rui Wang; Weiping Zhu; Yufang Xu; Xuhong Qian
• Keywords: Hypochlorite; Stokes shift; Fluorescence-lifetime imaging microscopy

A novel dual-emission fluorescence probe has been developed for specific and sensitive detection of hypochlorite (ClO−). Upon addition ClO−, significant changes in emission intensity at two discrete wavelengths were observed. Meanwhile OONO− led to only a single-channel enhancement. This feature makes it clear advantage distinguishing RNS from other ROS.