Gold catalyzed [3+2] cycloaddition of N-allenyl amides with azomethine imines

• DOI: 10.1039/c3cc41258j
• Publication Date: 2013-03-05T12:53:21Z
• Authors: Wen Zhou; Xiao-Xiao Li; Guo-Hua Li; Yun Wu; Zili Chen
• Keywords: Methylene; Azomethine ylide

Gold(I) catalyzed [3+2] cycloaddition of azomethine imines with N-allenyl amides was developed to provide two types pyrazolyl based bicyclic heterocycles. Both pyrazolidin-3-one derived and dihydroisoquinoline reacted smoothly give 6-methylene bipyrazolidin-1-ones 1-methylene hexahydropyrazolo[5,1-a] isoquinolines in moderate good yields.