Red blood cells decorated with functionalized core–shell magnetic nanoparticles: elucidation of the adsorption mechanism

• DOI: 10.1039/c3cc41513a
• Publication Date: 2013-04-18T09:17:25Z
• Authors: Thanh Duc Mai; Fanny d'Orlyé; Christine Ménager; Anne Varenne; Jean-Michel Siaugue
• Keywords: Erythrocytes; Surface Properties; Magnetic Phenomena; Static Electricity; Metal Nanoparticles; 02 engineering and technology; Silicon Dioxide; Ferric Compounds; 01 natural sciences; 3. Good health; 0104 chemical sciences; Microscopy, Electron, Transmission; Adsorption; 0210 nano-technology

The decoration of red blood cells (RBCs) with aminated and carboxylated core-shell magnetic nanoparticles (CSMNs) was studied and elucidated. It was demonstrated that only aminated CSMNs could decorate the RBCs and their adsorption interaction is mainly ruled by electrostatic attraction between the positively charged amino groups on CSMNs and the abundant sialic acid groups on the outer surface of RBCs.