Dextran based sensitive theranostic nanoparticles for near-infrared imaging and photothermal therapy in vitro

• DOI: 10.1039/c3cc43633k
• Publication Date: 2013-05-22T10:33:52Z
• Authors: Peng Liu; Caixia Yue; Bihua Shi; Guanhui Gao; Mingxing Li; Bi Wang; Yifan Ma; Lintao Cai
• Keywords: Diagnostic Imaging; Indocyanine Green; Cell Survival; Infrared Rays; Lasers; Dextrans; Hyperthermia, Induced; Phototherapy; 01 natural sciences; Fluorescence; 0104 chemical sciences; MCF-7 Cells; Humans; Nanoparticles

Indocyanine green (ICG) nanoparticles were developed via electrostatic interactions of ICG and dextran based block copolymers (PEG-dextran(-SS-NH2)) as near-infrared (NIR) theranostic nanoparticles. The nanoparticles could be activated from "OFF" to "ON" of NIR fluorescence in an intracellular environment and used for NIR imaging and photothermal therapy.