Direct 2-acetoxylation of quinoline N-oxides via copper catalyzed C–H bond activation

• DOI: 10.1039/c3cc43947j
• Publication Date: 2013-06-12T09:01:29Z
• Authors: Xuan Chen; Chongwei Zhu; Xiuling Cui; Yangjie Wu
• Keywords: Quinoline

An efficient and direct 2-acetoxylation of quinoline N-oxides via copper(I) catalyzed C–H bond activation has been developed. This transformation was achieved using TBHP as an oxidant in the cross-dehydrogenative coupling (CDC) reaction with aldehydes, provided a practical pathway to 2-acyloxyl quinolines.