Copper mediated stereoselective synthesis of C-glycosides from unactivated alkynes

• DOI: 10.1039/c3cc44250k
• Publication Date: 2013-08-22T08:31:32Z
• Authors: Anil Kumar Kusunuru; Madhubabu Tatina; Syed Khalid Yousuf; Debaraj Mukherjee
• Keywords: Glycal; Reaction conditions

A highly stereoselective rapid C-glycosylation reaction has been developed between glycal and unactivated alkynes in the presence of coppertriflate ascorbic acid at low catalyst loading room temperature. wide variety glycals aryl acetylenes participate smoothly. TfOH generated during reduction Cu(OTf)2 by may be active for glycosylation.