The mode of action of anticancer gold-based drugs: a structural perspective

• DOI: 10.1039/c3cc46400h
• Publication Date: 2013-08-30T15:02:39Z
• Authors: Luigi Messori; Federica Scaletti; Lara Massai; Maria A. Cinellu; Chiara Gabbiani; Alessandro Vergara; Antonello Merlino
• Keywords: Models, Molecular; crystal structure; Binding Sites; Molecular Structure; Gold Compounds; Lysozyme; x-ray crystallography; Anticancer drugs; Mechanism of action; Antineoplastic Agents; Crystallography, X-Ray; 01 natural sciences; 0104 chemical sciences; gold drugs; anticancer drugs; mechanism of action; Auranofin; Drug Design; Organometallic Compounds; cancer; Muramidase; Gold; Gold; crystal structure; cancer; Protein Binding

The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.