The mode of action of anticancer gold-based drugs: a structural perspective

• DOI: 10.1039/c3cc46400h
• Publication Date: 2013-08-30T15:02:39Z
• Authors: Luigi Messori; Federica Scaletti; Lara Massai; Maria A. Cinellu; Chiara Gabbiani; Alessandro Vergara; Antonello Merlino
• Keywords: Metalation; Mode of Action

The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug–protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds inherent protein metalation processes.