Celecoxib cocrystal polymorphs with cyclic amides: synthons of a sulfonamide drug with carboxamide coformers

• DOI: 10.1039/c3ce41885e
• Publication Date: 2013-09-23T14:10:29Z
• Authors: Geetha Bolla; Sudhir Mittapalli; Ashwini Nangia
• Keywords: Cocrystal; Synthon; Sulfonamide; Carboxamide

The trimorphic cocrystals of celecoxib with δ-valerolactam contain sulfonamide dimers and catemers together carboxamide dimers, whereas the caprolactam cocrystal is sustained by a SO2N–H⋯H–NOC heterosynthon. alternation synthons even–odd ring coformers offers crystal engineering approach to sulfonamide–carboxamide cocrystals.