A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids

• DOI: 10.1039/c3lc51093j
• Publication Date: 2014-01-06T15:36:52Z
• Authors: Janine Ruppen; Lourdes Cortes-De...; Emanuele Marconi; Golnaz Karoubi; Ralph A. Schmid; Renwang Peng; Thomas M. Marti; Olivier T. Guenat
• Keywords: Mesothelioma; 0301 basic medicine; 03 medical and health sciences; Cell Line, Tumor; Pleural Neoplasms; Spheroids, Cellular; 570 Life sciences; biology; Humans; 610 Medicine & health; Drug Screening Assays, Antitumor; Microfluidic Analytical Techniques; 3. Good health

This study reports on a microfluidic platform on which single multicellular spheroids from malignant pleural mesothelioma (MPM), an aggressive tumor with poor prognosis, can be loaded, trapped and tested for chemotherapeutic drug response.