Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors

• DOI: 10.1039/c3mb70145j
• Publication Date: 2013-07-05T12:42:04Z
• Authors: Chung-Min Park; Yu Zhao; Zhaohui Zhu; Armando Pacheco; Bo Peng; Nelmi O. Devarie-...; Powell Bagdon; Hui Zhang; Ming Xian
• Keywords: 0301 basic medicine; Muscle Cells; Molecular Structure; Cell Survival; Melanoma, Experimental; 610; 540; Phosphates; Mice; Oxidative Stress; 03 medical and health sciences; Animals; Humans; Hydrogen Sulfide

A series of O-aryl- and alkyl-substituted phosphorodithioates were designed synthesized as hydrogen sulfide (H2S) donors. H2S releasing capability these compounds was evaluated using fluorescence methods. O-aryl substituted donors showed slow sustained release while O-alkylated very weak capability. We also donors' protective effects against peroxide (H2O2)-induced oxidative damage in myocytes toxicity toward B16BL6 mouse melanoma cells.