The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials

• DOI: 10.1039/c3md00082f
• Publication Date: 2013-05-02T15:14:57Z
• Authors: Tolulope A. Aweda; Oluwatayo Ikotun; Tara Mastren; Carolyn L. Cannon; Brian Wright; Wiley J. Youngs; Cathy Cutler; James Guthrie; Suzanne E. Lapi
• Keywords: Biodistribution

Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate such compounds. Purified 111Ag incorporated into methylated caffeine analogue, IC1 yield silver carbene complex designated as [111Ag]SCC1 and investigated biodistribution studies.