Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(iii) compound

• DOI: 10.1039/c3mt00265a
• Publication Date: 2013-11-07T12:02:21Z
• Authors: Luigi Messori; Federica Scaletti; Lara Massai; Maria Agostina Ci...; Irene Russo Krauss; Giovanna di Martino; Alessandro Vergara; Luigi Paduano; Antonello Merlino
• Keywords: Bovine pancreatic ribonuclease; Pancreatic ribonuclease; Mode of Action

The reaction of Auoxo6, a dinuclear gold(iii) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on processes adduct formation enzyme inhibition and, inductively, likely mode action this metallodrug.