Multifunctional PEGylated nanoclusters for biomedical applications

• DOI: 10.1039/c3nr00774j
• Publication Date: 2013-04-29T10:30:45Z
• Authors: Erwin Peng; Eugene Shi Guang ...; Cherie Shi Hua Tan; Xiaosheng Tang; Yang Sheng; Junmin Xue
• Keywords: Nanoclusters; Biocompatibility

A simple and versatile synthesis method to form water soluble multifunctional nanoclusters using polyethylene glycol (PEG) functionalized poly(maleic anhydride-alt-1-octadecene) amphiphilic brush copolymers (PMAO-g-PEG) was presented. Simply by tuning the core size initial nanocrystal concentration, manganese ferrite nanoparticles (MFNPs) were used demonstrate versatility of loading amount nanoclusters. The resultant found have a well-controlled spherical shape. When Zn-doped AgInS2 quantum dots (AIZS QDs) loaded together with MFNP nanocrystals, bi-functional fluorescent magnetic behaviors obtained. Such also successfully demonstrated for cellular bio-imaging. Moreover, presence another type nanocrystals MFNPs negligible effect on overall properties as MR relaxivity test. From time-dependent colloidal stability test, it that PEG chain grafted onto PMAO able reduce protein adsorption nanocluster surface. An in vitro study NIH/3T3 biocompatibility biocompatible colloidally stable an approximate 80–120 nm suitable both MRI cell labeling applications.