Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor

• DOI: 10.1039/c3ob41483c
• Publication Date: 2013-08-24T08:31:42Z
• Authors: Peter Fodran; Adriaan J. Minnaard
• Keywords: Enantiopure drug; Glycidol

An efficient catalytic one-pot synthesis of TBDMS-protected diacylglycerols has been developed, starting from enantiopure glycidol. Subsequent migration-free deprotection leads to stereo- and regiochemically pure diacylglycerols. This novel strategy applied the a major Mycobacterium tuberculosis phospholipid, its desmethyl analogue, platelet activating factor.