PEGylation of fluoridated hydroxyapatite (FAp):Ln3+ nanorods for cell imaging

• DOI: 10.1039/c3py00489a
• Publication Date: 2013-05-08T09:04:28Z
• Authors: Xiaoyong Zhang; Junfeng Hui; Bin Yang; Yong Yang; Daidi Fan; Meiying Liu; Lei Tao; Yen Wei
• Keywords: PEGylation; Nanorod; Raft; Chain transfer; Surface Modification

PEGylation is a popular approach for the surface functionalization of nanoparticles to achieve improved properties and better performance. Herein, we developed facile method hydrophobic fluoridated hydroxyapatite (FAp):Ln3+ (Ln = Eu or Tb) nanorods via interactions between oleic acid amphiphilic synthetic copolymers, which were synthesized through reversible addition-fragmentation chain transfer (RAFT) polymerization using stearyl methacrylate (SMA) poly(ethylene glycol) (PEGMA) as monomers. Our results demonstrated that morphology fluorescent FAp are not significantly changed by procedure, resulting found be stable in aqueous solution. More importantly, these PEGylated biocompatible with cells could utilized cell imaging applications. Therefore, believe described this work simple, efficient general strategy nanoparticles.