Acid-induced disassemblable nanoparticles based on cyclic benzylidene acetal-functionalized graft copolymer via sequential RAFT and ATRP polymerization

Nanocarriers Raft Side chain
DOI: 10.1039/c3py01324c Publication Date: 2013-12-02T15:32:01Z
ABSTRACT
Polymeric nanoparticles assembled from the amphiphilic graft copolymer with cyclic benzylidene acetal-functionalized backbone and short poly(2-hydroxyethyl methacrylate) side chains can remain structurally stable at pH 7.4, but undergo stepwise disassembly in mildly acidic conditions due to acid-triggered cleavage of acetals, providing a promising nanocarrier for cancer therapy.
SUPPLEMENTAL MATERIAL
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