Scaffolds for bone tissue engineering: role of surface patterning on osteoblast response

• DOI: 10.1039/c3ra23315d
• Publication Date: 2013-02-21T10:30:30Z
• Authors: Jaba Mitra; Garima Tripathi; Ashutosh Sharma; Bikramjit Basu
• Keywords: Biocompatibility; Bioceramic; Nanotopography

The fabrication of tissue engineering scaffolds necessitates amalgamation a multitude attributes including desirable porosity to encourage vascular invasion, desired surface chemistry for controlled deposition calcium phosphate-based mineral as well ability support attachment, proliferation, and differentiation lineage specific progenitor cells. Scaffold often includes additional treatments bring about changes in the chemistry. In this perspective, review documents important natural synthetic fabricated bone applications tandem with treatment techniques maneuver biocompatibility engineered scaffolds. This begins discussion on fundamental concepts related characteristics biological micro-environment. primary focus is discuss effects micro/nano patterning modulation cell response. Apart from reviewing host experimental studies reporting functionality osteoblast-like cells stem modified or textured bioceramic/biopolymer scaffolds, theoretical insights predict behavior scaffold different topographical features are also briefly analyzed.