Visible-light degradable polymer coated hollow mesoporous silica nanoparticles for controlled drug release and cell imaging

• DOI: 10.1039/c3tb20922a
• Publication Date: 2013-07-09T12:15:51Z
• Authors: Shun Yang; Najun Li; Dongyun Chen; Xiuxiu Qi; Yujie Xu; Ying Xu; Qingfeng Xu; Hua Li; Jianmei Lu
• Keywords: Nanocarriers; Rhodamine; Rhodamine B

A core–shell nanocomposite based on photo-degradable polymer coated hollow mesoporous silica nanoparticles (HMS) was successfully prepared for targeted drug delivery and visible-light triggered release, as well fluorescence cell imaging. The HMS were first modified by the long-chain hydrocarbon octadecyltrimethoxysilane (C18) fluorescent agent Rhodamine B isothiocyanate (RITC), then encapsulated a photodegradable amphiphilic copolymer via self-assembly process. obtained nanocarrier showed high loading content due to core mesopores of could target folic acid receptor over-expressed tumor cells efficiently conjugating (FA) in polymer. release be irradiation green light (500–540 nm) photodegradation HMS. Furthermore, controlled processes tracked imaging doping RITC In vitro results suggested that smart visible responsive system potential applications cancer diagnosis therapy.