3D darkfield imaging and single particle tracking of peptide-coated nanocargoes in live cells

• DOI: 10.1039/c4ay01813c
• Publication Date: 2014-10-06T11:01:57Z
• Authors: Hui Shen; Bin Xiong; Ruili Xu; Xiaodong Cheng; Yan He; Edward S. Yeung
• Keywords: Tracking (education); Particle (ecology); Dark field microscopy

We present a 3D darkfield imaging method for tracking AuNPs. With this approach, we recorded the entire transmembrane process of cell-penetrating peptide (CPP) modified AuNPs from plasma membrane surface to deep inside cell.