The endocytic pathway and therapeutic efficiency of doxorubicin conjugated cholesterol-derived polymers

• DOI: 10.1039/c4bm00224e
• Publication Date: 2014-09-25T10:03:48Z
• Authors: Sema Sevimli; Sharon Sagnella; Alexander Macmillan; Renee Whan; Maria Kavallaris; Volga Bulmus; Thomas P. Davis
• Keywords: 0301 basic medicine; Polymers; Cells; Conjugated polymers; Gene; Cellular Uptake; Endocytic pathways; 03 medical and health sciences; Drug Delivery Systems; Polymethacrylic Acids; Cell Line, Tumor; Humans; Acid) Block-Copolymer; Mediated Endocytosis; Micelles; Antibiotics, Antineoplastic; Polyacrylates; Intracellular Trafficking; Photoelectron Spectroscopy; 500; Hep G2 Cells; Endocytosis; 3. Good health; Cholesterol; Doxorubicin; Dependent Internalization; Therapeutic efficiency; Nanoparticles; Cholesterol Esters; Transfection Efficiency; Drug; Delivery

Previously synthesized poly(methacrylic acid-co-cholesteryl methacrylate) P(MAA-co-CMA) copolymers were examined as potential drug delivery vehicles.