Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids

• DOI: 10.1039/c4cc03321c
• Publication Date: 2014-06-03T09:44:32Z
• Authors: Guobin Ma; Wen Wan; Qingyang Hu; Haizhen Jiang; Jing Wang; Shizheng Zhu; Jian Hao
• Keywords: Hydrocarbons, Fluorinated; Boronic Acids; Methylation; 01 natural sciences; Copper; 0104 chemical sciences; 3. Good health

A simple and highly efficient Cu-mediated gem-difluoromethylenation of a variety of aryl boronic acids with bromodifluoromethylated heterocyclic compounds has been disclosed. The transformations were performed in air at room temperature without ligands, bases, or additives.